Indeed, ALL cases with KMT2A-AFF1 have been subdivided in two distinct subgroups based on HOXA gene expression with the group with low HOXA expression showing the worst prognosis.45–48 However, our data suggest that the MLLGA that presented high HOXA gene expression show the worst overall survival in AML (Supplementary Fig. 5d). The gene discussed is AFF1; the disease is acute lymphoblastic leukemia.