DOT1L and acute myeloid leukemia: Interestingly, analysis of feature importance showed that the most relevant features for the ML model were phosphorylation sites on DOT1L (Fig. 2e), a protein highly associated to the biology of KMT2Ar-AML.26 Together, this analysis uncovered an 18-phosphopeptide signature that separates KMT2Ar-AML cases into two groups based on a ML model in which DOT1L phosphorylation is an important contributor.