DOT1L and acute myeloid leukemia: We found that MLLGA samples presented a significantly increased phosphorylation of sites in DOT1L, MLLT10, MLLT4 and EAF2 and a significantly reduced phosphorylation of AFF4 sites when compared to No-MLL (i.e., non-KMT2Ar cases) and MLLGB (i.e., KMT2Ar-AML cases that were not classified as MLLGA) (Fig. 3b).