A dysregulation of host proteolytic has been well characterized previously in IBD patients.8 In both CD and UC patients, increased host serine protease production from colonic tissue have been reported.27,28 Proteases such as cathepsin G and thrombin are overactive in supernatants of colonic tissues from IBD patients compared to healthy controls.8 Elastase-like activity has also garnered considerable attention in IBD. The gene discussed is CTSG; the disease is irritable bowel syndrome.