Specifically, TYK2 gene expression showed colocalized associations with systemic lupus erythematosus in lower leg skin (PP = 100%), whole blood (PP = 99%), artery tibial (PP = 98%), adrenal gland (PP = 98%), and stomach (PP = 91%), psoriasis in whole blood (PP = 99%), ulcerative colitis (PP = 97%) and inflammatory bowel disease (PP = 93%) in brain hypothalamus, Crohn's Disease in artery tibial (PP = 97%), oesophagus muscularis (PP = 92%), and oesophagus gastroesophageal junction (PP = 87%), and rheumatoid arthritis in whole blood (PP = 88%). This evidence concerns the gene TYK2 and Crohn disease.