Among patients with recurrent LM, univariable analysis revealed that longer interval between initial glioma and LM diagnoses (HR = 0.93, P < 0.001), gross total resection (HR = 0.60, P = 0.025) and chemotherapy (HR = 0.15, P = 0.001) were predictors of longer OS, while male sex (HR = 1.83, P = 0.009), histological grade 4 (P = 0.001), IDH wildtype (HR = 4.32, P = 0.001), and MGMT promoter unmethylation (HR = 2.00, P = 0.005) were predictors of shorter OS. The gene discussed is IDH2; the disease is glioma.