Overexpression in WT cases is consistent with the report of Ozawa et al.9 in which overexpression of PDGFA was predicted to be an early alteration in the pathogenesis of human non-GCIMP (i.e., IDH WT) GBM, and when overexpressed in p53 null mice, led to the generation of GBM-like tumors. Here, IDH2 is linked to glioblastoma.