A total of 30 genes were commonly dysregulated, including C3 (untreated HAND: d-score:6.894, fold change: 14.104, q: < 0.001; AD: d-score: 3.623, fold change: 1.971, q: < 0.001), C3aR1 (untreated HAND: d-score: 5.468, fold change: 4.018, q: < 0.001; AD: d-score: 4.400, fold change: 1.867, q: < 0.001), TLR7 (untreated HAND: d-score: 4.345, fold change: 8.197, q: 0.001; AD: d-score: 3.756, fold change: 1.945, q: 0.001), and DTNA (untreated HAND: d-score: 5.468, fold change: 4.018, q: 0.001; AD: d-score: 4.850, fold change:1.916, q: 0.001). Here, C3 is linked to Alzheimer disease.