A total of 14 genes were found shared between untreated HAND and AD, including IFIT3 (untreated HAND: d-score: 6.086, fold change: 10.542, q: < 0.001) (AD: d-score: −3.628, fold change: 0.580, q: < 0.001), ISG15 (untreated HAND: d-score: 6.491, fold change: 11.531, q: < 0.001, AD: d-score: −3.342, fold change: 0.611, q: < 0.001), and GBP1 (untreated HAND: d-score: 5.530, fold change: 9.495, q: < 0.001, AD: d-score: −3.352, fold change:0.585, q: < 0.001). Here, ISG15 is linked to Alzheimer disease.