ISG15 and Alzheimer disease: The comparison of the basal ganglia regions between AD vs. Control in GPL96 showed significant downregulation in ISG15 (AD: d-score:−4.095, fold change: 0.394, q: < 0.001) and STAT1 (AD: d-score:−3.909, fold change: 0.510, q: < 0.001).