SESN2 and metabolic dysfunction-associated steatotic liver disease: The disease spectrum of AFLD is similar to NAFLD and AFLD shares a large set of common pathological manifestations with NAFLD, such as hepatosteatosis, oxidative stress, ER stress, autophagy malfunction, etc. This suggests that the cytoprotective function and mechanism of SESN2 in AFLD may be analogous to that in NAFLD but still awaits further verification.