In monocytes, human acute monocytic leukemia cell line THP-1 cells for example, SESN2 is induced by LPS dose- and time-dependently, establishing a compensatory mechanism under p38 MAPK and PI3K activation by augmenting AMPK phosphorylation, decreasing NF-κB phosphorylation, and reducing secretion of pro-inflammatory cytokines (TNF-α, CCL2/MCP-1, and IL-6) [22, 61]. The gene discussed is CCL2; the disease is acute monocytic leukemia.