ALI is pathologically featured by extensive hepatocyte death and hypohepatia, which is generally caused by virus infection, drug abuse, hepatectomy, etc. Several studies collaboratively confirmed that preventative SESN2 overexpression can suppress galactosamine/LPS or acetaminophen-induced acute hepatocyte apoptosis and serum cytokine elevation, which is attributed to the antioxidative property of SESN2 [22, 77, 85]. This evidence concerns the gene SESN2 and viral infectious disease.