Furthermore, in a model of myocardial infarction, SESN2 is up-regulated in both pro-inflammatory M1 and anti-inflammatory M2 type cardiac macrophages, and SESN2 suppresses inflammatory response of M1 macrophages via inhibiting mTORC1 signaling and enhances M2 type macrophage polarization [79]. This evidence concerns the gene SESN2 and myocardial infarction.