According to the downregulation of UBB in the RT-PCR study, the possibility of its pathogenic actions in ATLL can be ruled out.miR-196a was shown to play roles in inflammation, embryonic development, and various cancers such as pancreatic adenocarcinoma, breast cancer, leukemia, esophageal adenocarcinoma, and colorectal cancer [83]. This evidence concerns the gene UBB and esophageal adenocarcinoma.