MiR-130a has a protective effect on cardiovascular diseases, for instance, Feng et al. found that miR-130a attenuated cardiac fibrosis after myocardial infarction through transforming growth factor (TGF)-β/Smad signaling by directly targeting TGF-β receptor 1 [33]. The gene discussed is TGFB1; the disease is myocardial infarction.