ABCD1 and X-linked adrenoleukodystrophy: C26:0-LPC, implicated in microglial dysfunction and brain diseases, is typically elevated in X-linked adrenoleukodystrophy, a hereditary peroxisomal disorder caused by mutations of the ABCD1 gene, required for the import of very long chain fatty acids into peroxisomes for β-oxidation [47, 48].