To investigate the effects of Menin-MLL inhibitors on global gene expression in MLL1-rearranged leukemias, we performed RNA-seq with RNA from a human MLL1-r AML cell line (MOLM-13) and patient-derived primary AML with MLL1-r (NCCHD010) cells treated with DS-1594a·succinate for 3 and 7 days, respectively. This evidence concerns the gene KMT2A and leukemia.