The aim of this study is to investigate whether PAI-1/t-PA is involved in mucosal tissue remodeling in the early stage of nasal polyps, and to further explore the expression and mechanism of TGF-β1/PAI-1/Col-1 axis in mNP, to provide insights for precise clinical treatment of nasal polyps. This evidence concerns the gene SERPINE1 and Nasal polyposis.