TP53 and Alzheimer disease: We found that the combination of stab-wound injury, p53 loss, and microglia-mediated inflammation was sufficient to recapitulate the phenotype of injured and aged p53Gfap-icKO brains, leading to the formation of AD-tdTomato+ cells, a subset of which were lowly proliferative AD-tdTomato+-NSCL cells (Figures 3B–3E and S3F–S3H).