Strikingly, EGF infusion phenocopied p53 effects observed in both young and aged brains: in p53Gfap-wt/wt mice, it induced the formation of AD-tdTomato+ cells to an extent similar to p53 deletion in young injured brains (Figures 4E and 4F); in p53Gfap-icKO mice it increased the overall proportion of AD-tdTomato+ cells and, as in the aged and LPS-treated brain, selectively led to their progression to AD-tdTomato+-NSCL cells, as judged by the presence of doublets, Ki67+ and Sox2+/Olig2+/Ascl1+ AD-tdTomato+ cells (Figures 4E–4G and S4C–S4H). This evidence concerns the gene OLIG2 and Alzheimer disease.