MYC and neoplasm: Lastly, MG4 meningiomas, consisting of the most aggressive and “proliferative” meningiomas, were enriched for cell cycle regulation pathways including MYC, FOXM1, E2F, etc. Using single cell RNAseq (scRNAseq), we found limited intratumoral heterogeneity in most meningiomas, with most neoplastic cells of a given patient’s tumor resembling the molecular signatures of the bulk tumor.