MG2 meningiomas were instead enriched for non-NF2 mutations AKT1, TRAF7, KLF4, and POLR2A. We also identified novel somatic driver mutations in our aggressive MG3 and MG4 meningiomas, including chromatin remodeling and epigenetic regulators KDM6A, CHD2, and the tumor suppressor PTEN. Our most aggressive group, MG4 had the highest mutational burden compared to all other MG. The gene discussed is POLR2A; the disease is meningioma.