The first genetic alteration identified in meningiomas arose from patients with neurofibromatosis 2 (NF2), an autosomal dominant tumor syndrome caused by biallelic inactivation of the NF2 gene, resulting in meningiomas that affect up to half of these patients in addition to pathognomonic development of bilateral vestibular schwannomas [4–7]. This evidence concerns the gene NF2 and Vestibular schwannoma.