Cheng and coworkers observed in the GBM cell line U-87MG that the suppression of motility and migration after treatment with Ouabain (2.5 to 25 μmol/l) correlated with a down-regulation of phosphorylated Akt (p-Akt) also called protein kinase B (PKB), hypoxia-inducible factor 1-alpha (HIF-1α) and phosphorylated mammalian target of rapamycin (p-mTOR) [47]. Here, AKT1 is linked to glioblastoma.