GPT and neoplasm: In contrast, some serum biochemical indicators reflecting liver functions, such as AST and ALT became abnormal when the mice were administrated with naked free sgCas9‐AdV (Figure S11, Supporting Information), probably ascribing to the diffusion of AdV from tumor to liver which cause hepatotoxicity (Figure S9, Supporting Information).[38] Taken together, these results document the high potential of silk‐gel, as a biocompatible platform to improve therapeutic efficiency of AdV‐based CRISPR/Cas9 system targeting PD‐L1.