PTEN and hepatocellular carcinoma: PTEN mainly acts as a phosphatase which dephosphorylates phosphatidylinositol triphosphate and thus negatively regulates PI3K‐dependent Akt/mTOR signaling.[17] It was first discovered as a tumor suppressor, and hepatocyte‐specific Pten deficiency resulted in hepatocellular carcinomas in mice.[39, 40] However, emerging evidence has highlighted the role of PTEN in protecting liver against acute injury.[41, 42] With the help of transcriptome sequencing, we hypothesized that PTEN pathway negatively regulates hepatic ME1 transcript and thus contributes to I/R‐induced ferroptosis.