IDH3A and hepatocellular carcinoma: The PPP is an important glucose metabolism pathway, in which NADPH is produced by both glucose‐6‐phosphate dehydrogenase (G6PD) and 6‐phosphogluconate dehydrogenase.[27] Knockdown of G6PD has been proven to inhibit ferroptosis in hepatocellular carcinoma cell lines.[28] In addition to the oxidative PPP, quantitative flux analysis has revealed that intracellular NADP+ could also be recycled to NADPH by folate‐mediated one‐carbon metabolism, malic enzymes, and isocitrate dehydrogenases.[29]