CRSwNP patients characterized by eosinophilic inflammation and type 2 inflammation have high levels of immunoglobulin (Ig) E, interleukin (IL‐5), IL‐4 and IL‐13 in local tissues, often accompanied by eosinophilia in peripheral blood.31, 34, 35. This evidence concerns the gene IL4 and chronic rhinosinusitis with nasal polyps.