On the other hand, the extract contains artepillin C (ArtC) which attaches to mortalin-p53 complexes, causing the activation of the p53 protein and arresting the growth of cancer cells such as HT1080 (human fibrosarcoma), A549 (human lung cancer), and U2OS (human osteosarcoma) [53]. The gene discussed is TP53; the disease is osteosarcoma.