IGHE and atopic eczema: Under uncertain conditions to overproduce IL-2, IL-10, and TGF-β from T cells and macrophages, the acute phase of allergic inflammation can be switched to chronic allergy and atopic dermatitis conditions, under which T-cell proliferation is increased, IL-4, IL-5, and GM-CSF are overproduced, and IgE and IgM are highly produced [12,13].