The impact of GCEO on oxidative status was evaluated in the SCOP-induced zebrafish model of cognitive impairment by measuring the specific activities of antioxidant defense enzymes, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX), and the levels of malondialdehyde (MDA), the main product of lipid peroxidation, and carbonylated proteins, the product of protein oxidation. This evidence concerns the gene SOD1 and Cognitive impairment.