It has been demonstrated that prenylated xanthone α-mangostin and gambogic acid are inhibitors of MDM2-p53 interaction [309], while the pyranoxanthone has shown a promising growth inhibitory activity as a putative inhibitor of MDM2-p53 interaction in human tumor cells expressing wild-type p53 and overexpressed MDM2 [308]. Here, MDM2 is linked to neoplasm.