Gold particles with a size of 106.7 nm with quercetin, have also been reported in liver cancer and the effects included release of cytochrome c through cleavage of caspase-3 and caspase-9, decrease in COX-2 via suppression of NF-κB nuclear translocation and its binding to the COX-2 promoter and the inactivation of Akt and ERK1/2 signaling pathways [84]. The gene discussed is CYCS; the disease is liver cancer.