Arecoline, a potential carcinogen, and Timosaponin AIII, a type of steroid saponin, were found to exert either pro-carcinogenic or anti-metastatic effects on lung cancer cells by regulating the expression of MMPs through the EGFR/Src/FAK and ERK/Src/FAK signaling pathways [13,48]. This evidence concerns the gene PTK2 and lung carcinoma.