PIK3CA and cancer: Even so, despite the great diversity, over the years, it has become more apparent that only certain kinases are among the most frequently occurring drivers of human cancer, including tyrosine receptors (RTK) (i.e., FGFR, EGFR, VEGFR, RET, MET, ALK), members of the PI3K/AKT/mTOR and Mitogen-Activated Protein Kinase (MAPK) pathways, along with central coordinators of cell cycle progression (i.e., cyclin-dependent kinases) and chromosome segregation such as polo-like and aurora kinases [25].