MKI67 and neoplasm: Moreover, expression profiling of pediatric brain tumors has shown that AURKA was consistently and highly overexpressed (up to 106-fold) in tumor samples from all glioma grades and from patients varying from 4 months to 82 years old; however, mRNA expression showed only weak correlation with the Ki-67 labeling index, and significant associations with poor patient survival were only observed for GBM [530].