Similar results were observed in a panel of NB cell lines (with genetic backgrounds differing in MYC, p53 and BCL2 statuses), where this inhibitor was the most effective compound in reducing cell proliferation (compared to BiCNU, docetaxel, flavopiridol, staurosporine) and induced apoptosis measured through both caspase activation and caspase-3 and PARP cleavage [837]. The gene discussed is TP53; the disease is neuroblastoma.