Moreover, in RMS, PLK1 inhibition by BI 2536 led to elevated ubiquitination and rapid proteasomal degradation of the PAX3-FOXO1 chimeric oncoprotein in vitro, whereas it reduced PAX3-FOXO1-mediated gene expression and elicited tumor regression in a xenograft mouse model [900]. The gene discussed is PLK1; the disease is neoplasm.