FGFR4 and neuroblastoma: Last but not least, a germline polymorphism in the FGFR4 gene (rs351855) which results in the expression of an arginine at codon 388 (Arg388), rather than the more common glycine (Gly388), is frequently associated with decreased survival rates, treatment resistance and more aggressive disease in a variety of malignancies, and is associated with an increased prevalence of NB in children [85], and this association may be linked to differences in FGFR4 degradation rates [86].