Treatment also decreased (p)RET expression in five other NB cell lines and strongly impaired tumor growth in vivo in both MYCN/KI AlkR1279Q and MYCN/KI AlkF1178L mice, and was able to sensitize cisplatin-resistant NB subcutaneous tumor growth with less severe liver toxicity compared with high-dose cisplatin [598,599,600]. The gene discussed is RET; the disease is neuroblastoma.