CDK4 and sarcoma: Perez et al. (2015), by treating a panel of 10 low-passaged sarcoma cell lines generated directly from patient samples and two commercial cell lines of heterogeneous origin and different molecular karyotypes (including liposarcoma, leiomyosarcoma, EWS, RMS and myxofibrosarcoma), determined IC50 values ranging from 8 to 26 μM depending on their levels of CDK4 expression.