Even though there is no well-established relationship between this kinase and the development of this tumor type, Zhang et al. (2016) [366] demonstrated that the inactivation of TAZ (a biomarker of aggressiveness in RB through miR-125a-5p) inhibited proliferation and tumor formation by decreasing cyclin E and CDK2 expression [367]. This evidence concerns the gene CDK2 and neoplasm.