Likewise, its potential to increasingly suppress growth factors, including TP53, Rb, and p57Kip2, as well as downturn-related proliferation pathways, such as phosphatidylinositol-3 kinase (PI3K), Janus kinase-(JAK)-STAT, wingless-related site (Wnt)-Beta-catenin, Sonic Hedge-hog, activator protein 1 (AP1), mitogen-activated protein kinases (MAPK), transforming growth factor-beta (TGF-β), and NF-κB, acts against angiogenesis [angiopoietin and vascular endothelial growth factor (VEGF)] and enhances apoptosis in various cancers [69]. Here, VEGFA is linked to cancer.