Moreover, MH-mNPs showed a greater cytotoxic effect compared to NPs not containing TPGS (MH-NPs), probably because of the synergistic antitumor activity of TPGS in the presence of the flavonoid caused by TPGS’s ability to induce ROS-generation and cancer cells apoptosis, as well as by the combination of MH and TPGS ability to inhibit P-glycoprotein (P-gp) expressed in the cells, thus reducing drug efflux. Here, ABCB1 is linked to cancer.