They utilized a charge-altering releasable transporter mRNA delivery platform to induce the local expression of cytokines (CD70, IL-12, and IFN-γ) and costimulators (OX40L, CD80, and CD86) individually and in combination in two tumor models (A20B-cell lymphoma and CT26 colon carcinoma). The gene discussed is TNFSF4; the disease is neoplasm.