LDLR and neoplasm: LDLR expressing tumour cells were consistently observed to localize within perivascular areas, consistent with seminal studies by Calabrese et al., in 2007, across a host of primary brain tumours, notably glioblastoma, ependymoma, medulloblastoma and oligodendroglioma, where cancer stem cells (CSCs) were shown to associate in close proximity to tumour capillaries creating vascular niches.