Moreover, studies have demonstrated that PGC-1α knockout mouse models are more susceptible to AKI from various causes while renal tubule specific overexpression of PGC-1α has been linked to AKI resistance, especially in cases of cisplatin-induced AKI and ischemia-reperfusion injury [25,26,27]. The gene discussed is PPARGC1A; the disease is ischemia reperfusion injury.