It was shown that curcumin can attenuate inflammation, renal fibrosis, and oxidative stress through the nuclear factor-erythroid-2-related factor (Nrf2) Kelch-like erythroid cell-derived protein with cap-n-collar homology-associated protein 1 (Keap1) pathway in rats subjected to 5/6 nephrectomy, suggesting its potential in the treatment of CKD [169]. The gene discussed is NFE2L2; the disease is renal fibrosis.