RNA sequencing studies revealed that through the expression of a long non-coding RNA, referred to as taurine-upregulated gene 1 (Tug1), an upstream activator of PGC-1α was reduced in the diabetic glomeruli and podocytes while podocyte-specific over-expression of Tug1 resulted in improved histological changes in response to hyperglycemia [36]. Here, TUG1 is linked to Hyperglycemia.