Khoobchandani et al. designed mangostin-functionalized gold nanoparticles (MGF-AuNPs), which modulated the balance between pro-tumor M2 and anti-tumor M1 macrophages, increased the expression of anti-tumor cytokines such as IL-12 and TNF-α, and decreased the expression of pro-tumor cytokines such as IL-10 and IL-6 in prostate cancer-bearing mice [113]. This evidence concerns the gene IL6 and neoplasm.