Compared with BPBBT-HSA NPs, although BPBBT micelles exhibited a longer systemic circulation time (t1/2β = 10.00 v.s. 3.58 h), the micelles contributed much less to tumor accumulation, leading to their AUCtumor0→48h only 14% of that of BPBBT-HSA NPs. Here, ALB is linked to neoplasm.