However, and more importantly, employing photothermal therapy (PTT) by photoabsorber Ph556 converting light to heat for tumor thermal ablation caused a synergistic effect between IPN nanoparticles and wrapped TRAIL protein by upregulating the expression of the TRAIL death receptors DR4 and DR5, resulting in the synergistic effects between PTT and TRAIL therapy. Here, TNFSF10 is linked to neoplasm.