ARC and Alzheimer disease: To this aim, the impact of 12A12mAb immunization on the visual-dependent behavioral performance of symptomatic Tg2576 AD mice was evaluated in tight correlation with the assessment of two specific, morphological (dendritic spine density including cofilin 1 phosphorylation) and biochemical (experience-dependent expression of the activity-regulated cytoskeleton protein Arc/Arg3.1) readouts of synaptic plasticity in the primary visual cortex.