Interestingly, a robust increase in Arc/Arg3.1 expression was detectable following 12A12mAb immunization (one-way ANOVA followed by Bonferroni’s post hoc test; **** p < 0.0001 Tg2576+mAb vs. Tg2576), indicating that immunization of the Tg2576 AD cohort markedly recovered the normal sensory-dependent functional plasticity of their visual cortices. The gene discussed is ARC; the disease is Alzheimer disease.