MAPT and Alzheimer disease: Additionally, subjects with MCI or full-blown frank dementia, exhibit dense neurofibrillary tangles (NFTs), neuropil threads, and tau-immunoreactive neurites surrounding neuritic plaques (NPs) in their primary visual cortex (Brodmann Area 17) [157,161,162] and visual association cortex (Brodmann area 19) [158], indicating that the occurrence of tau pathology in these high-order structures is more likely to be causative for the early alterations of visual signal processing occurring during the AD progression.