ARC and Alzheimer disease: As shown (Figure 4A–C), the cytosolic extent of Arc/Arg3.1 dot-like labeling was strongly lower in 6-month-old Tg2576 AD mice when compared to their age-matched controls (one-way ANOVA followed by Bonferroni’s post hoc test; **** p < 0.0001 Tg2576 vs. wild-type).