ARC and Alzheimer disease: On the contrary, the amplitude of Arc responses was largely upregulated following 12A12mAb delivery (one-way ANOVA followed by Bonferroni’s post hoc test; **** p < 0.0001 Tg2576+mAb vs. Tg2576), indicating that the percentage of neurons activated by visual incentive in relevant cortical networks in the Tg2576 AD cohort was significantly higher than in their not-vaccinated counterparts, consistent with their improved performance following sensory experience (Figure 2).