APP and Cognitive impairment: In contrast to the tauopathy animal model that does not show amyloidosis, Tg2576 overexpressing the APP695 isoform with the Swedish mutation APP KM670/671NL (TgHuAPP695swe) displays progressive hippocampus-based synaptic and cognitive impairments, ocular disturbances depending on both Aβ and tau pathologies [12,42,46,51,71] and, thus, better mirrors important aspects of human AD pathology [71].