APP and Alzheimer disease: As shown in Figure 5C,D, the P-cofilin 1 signal significantly decreased in 6-month-old Tg2576 AD animals when compared with littermate wild-types (* p < 0.05 Tg2576 vs. wild-type), in line with previous results in AD mouse models, such as APP/PS1 and 3 × Tg and affected patients [119,120,121,122,123,124].