As shown in Figure 3A,B and in line with previous results reporting that Arc/Arg3.1 activation following sensory incentive was greatly impaired in the visual cortex from APP/PS1 AD mice [98,99,100], the synaptic response to physiological consolidation of visual experience was disrupted in 6-month-old Tg2576 AD animals when compared to their littermate wild-types (one-way ANOVA followed by Bonferroni’s post hoc test; ** p < 0.01 Tg2576 vs. wild-type). The gene discussed is APP; the disease is Alzheimer disease.