MAPT and Alzheimer disease: Thus, having established that the aberrant expression of truncated tau was elevated not only in the retina but also in the V1 area from Tg2576 AD mice, we further assessed whether its occurrence into the visual pathway was correlated with their poor performance in visual acuity and whether its in vivo immunoneutralization following 12A12mAb treatment was beneficial to this classical vision disturbance associated with AD symptomatology.