In particular, deficits in visual system function have been described in experimental AD animal models [2,3,4,5,6,7,8,9,10,11,12] and in affected patients [13,14,15,16,17,18,19,20,21,22] consistent with the extensive neuropathology of Aβ plaques and tau neurofibrillary tangles (NFT) in their visual primary and association cortices and sensory system, including the optic nerves and retina themselves. Here, MAPT is linked to Alzheimer disease.