Next, we evaluated whether the morphological alterations of spine density detected in the primary visual cortex of 6-month-old animals from three experimental groups (littermate wild-type, vehicle-treated Tg-AD, Tg-AD+mAb) were also associated with corresponding modulation in its biochemical correlate, such as the expression level and phosphorylation pattern of cofilin 1 [113,114,115]. This evidence concerns the gene CFL1 and Alzheimer disease.