ARC and tauopathy: On one hand, no relationship between tau insoluble neurofibrillary tangles (NFT) and differential Arc expression in the cortical V1 area has been reported in rTg4510, a transgenic mouse model of tauopathy overexpressing the P301L mutant form of human tau driven under a tetracycline-operon responsive element that is suppressible with doxycycline (DOX) [97].