PROM1 and glioblastoma: In another study, Kim JS et al. [84] have designed a strategy to improve TMZ delivery to the stem cell compartment in a GBM orthotopic mouse model by conjugating a TMZ-encapsulating immuno-liposome with Angiopep-2 (ANG) mAB (for BBB transcytosis) and CD133 mAB (for specifically target GBM stem cells).