APOA1 and neoplasm: Cloning of the Apo-A1 gene into the downstream sequence of the CD63 in donor cells produced exosomes that expressed Apo-A1 on the surface of bilayer lipid membranes, and these exosomes were specifically recognized by scavenger receptor class B1 positive hepatocellular carcinoma cells, thereby enhancing the tumor targeting of the exosomes.