For example, nanoencapsulation of two murine melanoma antigenic peptides, gp100(25–33) (KVPRNQDWL) and TRP-2(180–188) (SVYDFFVWL) by biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanoparticle, showed very different efficacy depending on the hydrophilicity of the two peptides. Here, PMEL is linked to melanoma.