Noteworthily, the degradation of BRD4 by ARV-825 not only induced the apoptosis of glioma cells, but also suppressed the tumor-infiltrated M2 macrophage via inhibiting the transcription of downstream IRF4 promoter and the phosphorylation of STAT6, STAT3, and AKT. The gene discussed is BRD4; the disease is glioma.