A microscopic analysis of tumor sections obtained 24 h after the last injection of saline, L19-mIFNγ KRG, anti-PD-1 or the combination revealed a substantial increase in the density of CD4+ T cells, CD8+ T cells and NK cells only in mice treated with the combination L19-mIFNγ KRG + anti-PD-1 in both CT26 (Figure 6) and WEHI-164 (Figure 7) tumor models. This evidence concerns the gene CD8A and neoplasm.