Some studies that employ PDT as an in-situ vaccination strategy show, in particular for vascular-targeted PDT, enhanced activation of tumor-specific antitumor CD8+ T cells against cancer cells expressing exogenously introduced antigens [152,163,164], HPV E6/7 oncoproteins [165], cancer/testis antigen P1A [166], and murine colon 38 (MC38) neoepitopes [131]. This evidence concerns the gene CD8A and neoplasm.