We carried out a study on a large (n = 407) cohort of patients with advanced CKD (serum creatinine ≥ 2 mg/dL) in the predialysis stage; in an age-matched study, a comparison of serum aminotransferase values of patients with advanced CKD with those of healthy groups (age > 60 years) showed that AST and ALT levels were lower in advanced CKD (AST 17.4 ± 8 vs. 22.3 ± 6 (p = 0.0001) and ALT 16.3 ± 9 vs. 20.8 ± 10 (p = 0.008)) [21]. The gene discussed is GPT; the disease is chronic kidney disease.