ORAI1 and Anhidrotic ectodermal dysplasia: Activation of T cell receptors and B cell receptors results in activation of calcium release channels in the plasma membrane, including the well-studied CRAC (calcium release - activating calcium channels), of which ORAI1 is the pore - forming subunit [113].Patients with ORAI1 deficiency have features of adaptive immune deficiency, congenital myopathy and anhidrotic ectodermal dysplasia with enamel defects of the teeth and dry skin and heat intolerance as a result of anhidrosis.