Bacterial skin infections, especially furuncles and abscesses that lack signs of inflammation, the ‘cold abscesses’ are a hallmark of autosomal dominant loss of function Hyper IgE syndrome [68], while disseminated mucocutaneous viral infections like warts and molluscum contagiosum occur in autosomal recessive Hyper IgE syndrome due to DOCK8 variants apart from eczema, abscesses and mucocutaneous candidiasis [41,42]. This evidence concerns the gene DOCK8 and abscess.