The contribution of interactions between human toxoplasmosis and the inflammatory process indicates that the expression of IL-1 in human monocytes depends on ASC and caspase-1, which is an adapter protein that binds caspase-1 to NLRP3/CARDB or NLRP1/caspase-5 in the flammomasome [198]. The gene discussed is NLRP1; the disease is toxoplasmosis.