ALOX12 and toxoplasmosis: Similarly, the gene Arachidonate 12-lipoxygenase, type 12S (ALOX12), which encodes the arachidonate 12-lipoxygenase enzyme, has alleles related to toxoplasmosis, and ALOX12 knockdown prevents the proliferation of T. gondii tachyzoites by aggregating RCD [181].