There was a significant increase in Plasmodium falciparum T-cell specific circumsporozoite protein (CSP) responses, expansion in the amplitude of the αCSP IgG response, and increased inhibition of sporozoite invasion in hepatocytes with CSP-p (Man-TLR7), as compared with CSP, formulated with MPLA/QS-21 -loaded liposomes, the adjuvant used in the most clinically advanced malaria vaccine [71]. Here, DNAJC5 is linked to malaria.