NET components such as dsDNA, histones, MPO, vimentin, and enolase have been associated to systemic pathology linked with disease entities such as small vessel vasculitis, systemic lupus erythematosus (SLE), disseminated intravascular coagulation, preeclampsia, and rheumatoid arthritis [85,86]. This evidence concerns the gene MPO and systemic lupus erythematosus.