Upregulated genes such as DHRS2, ID2 [32], CCNA1 [33], EGR2 [34], WNT4 [35], RIPK4 [36], PDK4 [37], IL-11 [38], and MAPK4 play a role in promoting the development of colon cancer and various malignancies [39]. Here, MAPK4 is linked to colonic neoplasm.