As a result, IL-22 may be both proinflammatory and profibrogenic in hepatitis B. In addition, elevated circulating levels of Th22 correlated with the severity of HBV-associated acute–chronic liver failure (HBV-ACLF), suggesting that Th22 cells are a negative predictor of prognosis in HBV-ACLF [89]. This evidence concerns the gene IL22 and hepatitis B virus infection.