The increased expression of HML-2 in RA patients found by Freimanis et al. was also reflected by an increased titer of autoantibodies against a recombinant peptide derived from the antigenic region of HERV-K10 Gag1 that shares homology with Collagen II, suggesting a direct link between elevated HML-2 expression, anti-HML-2 autoantibodies, and anti-Collagen II autoantibodies [135]. Here, CLEC10A is linked to rheumatoid arthritis.