CLEC10A and rheumatoid arthritis: The increase in HML-2 expression was confirmed by Reynier et al., who demonstrated that both types of HML-2 (HML-2 type I and type II) are significantly upregulated in the synovial fluid of RA patients compared to OA patients and healthy controls, with a higher HML-2 type I viral load associated with increased disease activity in RA patients [136].