CLEC10A and systemic lupus erythematosus: Following these findings, the Tokuyama group analyzed the HML-2 subfamily due to its high degree of coding competence compared to other families and found that 4 of the 12 HML-2 loci (HERV-K102, -K106, -K110, and -K115) with envelope-coding sequences are significantly upregulated in SLE PBMCs [141].