IL6 and Anxiety: The animal model study [46] suggests that high-fat-fed rats accompany anxiety and depressed behavior with an increase in glucose intolerance and inflammatory cytokines such as IL-1, IL-6, and TNFlevels; they also found that treating with a P2 × 7 receptor antagonist, which blocks activation of the inflammasome, can block the behavioral abnormalities induced by a high-fat diet [56].