In the first and third trimesters serum zinc levels were lower, serum copper levels were higher, the Zn / Cu ratio decreased and serum magnesium levels were higher in the COVID-19 positive group In the second trimester COVID-19 patients had lower serum zinc and copper levels compared to negative controls Zn/Cu ratio showed correlation with inflammatory and acute phase markers including IL-6, CRP, ESR, procalcitonin. The gene discussed is ESR1; the disease is COVID-19.